Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors.
Cesar SerranoAna VivancosAntonio López-PousaJudit MatitoFrancesco M MancusoClaudia ValverdeSergi QuirogaStefania LandolfiSandra CastroCristina DopazoAna SebioAnna C VirgiliMaría M MensoJavier Martín-BrotoMiriam SansóAlfonso García-ValverdeJordi RosellJonathan A FletcherSuzanne GeorgeJoan CarlesJoaquín ArribasPublished in: BMC cancer (2020)
ctDNA evaluation with amplicon-based NGS detects KIT primary and secondary mutations in metastatic GIST patients, particularly after imatinib progression. GIST exhibits low ctDNA shedding, but ctDNA monitoring, when positive, reflects tumor dynamics.