Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks.
Gaia FumagalliMichael S ChristodoulouBenedetta RivaInigo RevueltaCristina MarucciVeronica CollicoDavide ProsperiSergio RivaDario PerdicchiaIvan BassaniniAida García-ArgáezLisa Dalla ViaDaniele PassarellaPublished in: Organic & biomolecular chemistry (2018)
The ability of 4-(1,2-diphenylbut-1-en-1-yl)aniline as a self-assembly inducer is reported. The conjugation of this moiety with aloin or podophyllotoxin resulted in spherical nanoparticles that were characterized by Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM) and NanoSight technology. A preliminary biological evaluation on two cancer cell lines is reported.