TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes.

Genghuan WangJian ShenLiping ZhaiYingcong LinQiaobing GuanHeping Shen

Published in: CNS neuroscience & therapeutics (2023)

Our results demonstrate that TL1A plays an important role in POCD in mice, which promotes the A1 differentiation of astrocytes through NLRP3, thereby exacerbating the progression of cognitive dysfunction.

Keyphrases

high fat diet induced
patients undergoing
nlrp inflammasome
wild type
adipose tissue
skeletal muscle