Brain MRI activity during the year before pregnancy can predict long-term clinical worsening in patients with Multiple Sclerosis.
Shahar KahilaOmri ZveikNetta LevinLivnat BrillAriel RechtmanNitzan HahamTal ImbarAdi Vaknin-DembinskyPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
An active MRI pre-conception is a strong predictor of lt-EDSS and a higher annual relapse rate during the follow-up period, regardless of whether the female had clinical evidence of disease activity prior to conception and delivery. Optimizing disease control and achieving imaging stability prior to conception may reduce the risk of long-term clinical deterioration.