Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.

Orhan Sahin Gozde Akturk Serap Cilaker Micili Özlem Gürsoy Doruk Fazilet Karapinar Nil Hocaoglu Bekir Uğur Ergür Pinar Akan Yesim Tuncok Sule Kalkan

Published in: The Journal of pharmacy and pharmacology (2023)

Our results suggest that nicorandil, a selective mitochondrial KATP channel opener, plays a protective role in amitriptyline-induced QT prolongation and myocardial damage. Mitochondrial KATP channel opening and anti-apoptotic effects may play a role in the cardioprotective effect of nicorandil.

Keyphrases

oxidative stress
drug induced
diabetic rats
cell death
high glucose
heart failure
endothelial cells
atrial fibrillation