Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis.

Shaun HaranKantaraja ChinderaMay SabryNafisa WilkinsonRupali AroraAgnieszka ZubiakThomas E BartlettIona EvansAllison JonesDaniel ReiselChiara HerzogTwana AlkasaliasMark NewmanJaeyeon Kim Angelique Flöter Rådestad Kristina Gemzell-DanielssonAdam N RosenthalLouis DubeauMark W Lowdell Martin Widschwendter

Published in: Cancers (2024)

mutation carriers, either systemically or locally, may favor site-specific pre-invasive carcinogenesis. These cumulative effects across a reproductive lifecycle in high-risk carriers can have a detrimental effect further supporting epidemiological evidence for ovulation inhibition.

Keyphrases

single cell
cell therapy
postmenopausal women
oxidative stress
polycystic ovary syndrome
breast cancer risk
stem cells
metabolic syndrome
risk assessment