DGIdb: mining the druggable genome.

Malachi GriffithObi L GriffithAdam C CoffmanJames V WeibleJosh F McMichaelNicholas C SpiesJames KovalIndraniel DasMatthew B CallawayJames M EldredChristopher A MillerJanakiraman SubramanianRamaswamy GovindanRunjun D KumarRon BoseLi DingJason R WalkerDavid E LarsonDavid J DoolingScott M SmithTimothy J LeyElaine R MardisRichard K Wilson

Published in: Nature methods (2013)

The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http://dgidb.org/.

Keyphrases

genome wide
genome wide identification
genome wide analysis
dna methylation
copy number
transcription factor
bioinformatics analysis
adverse drug
gene expression
emergency department
drug delivery