Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.
Kristina M Adams WaldorfJennifer E Stencel-BaerenwaldRaj P KapurColin StudholmeErica BoldenowJay VornhagenAudrey BaldessariManjiri K DigheJeff ThielSean MerillatBlair ArmisteadJennifer Tisoncik-GoRichard R GreenMichael A DavisElyse C DeweyMarian R FairgrieveJ Christopher GatenbyTodd RichardsGwenn A GardenMichael S DiamondChristopher M TraudtRichard F GrantLaRene KullerDennis W W ShawJason OgleG Michael GoughWonsok LeeChris EnglishRobert F HevnerWilliam B DobynsMichael GaleLakshmi RajagopalPublished in: Nature medicine (2016)
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.