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Single-Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment.

Anuja SatheSusan M GrimesBilly T LauJiamin ChenCarlos J SuarezRobert J HuangGeorge PoultsidesHanlee P Ji
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Single-cell gene expression studies revealed widespread reprogramming across multiple cellular elements in the gastric cancer TME. Cellular remodeling was delineated by changes in cell numbers, transcriptional states, and intercellular interactions. This characterization facilitates understanding of tumor biology and enables identification of novel targets including for immunotherapy.
Keyphrases
  • single cell
  • gene expression
  • rna seq
  • high throughput
  • dna methylation
  • transcription factor
  • stem cells
  • oxidative stress
  • bone marrow
  • cell therapy
  • genome wide
  • case control
  • heat shock protein