Bcat2-Mediated Branched-Chain Amino Acid Catabolism Is Linked to the Aggravated Inflammation in Obese with Psoriasis Mice.

Yazhuo WangNing ZhaoYujiao MengJia ChenCong QiXueqing HuHaoyue ZhuDanyang YangXiawei ZhangHuike MaJingxia ZhaoTingting DiPing LiJingxia Zhao

Published in: Molecular nutrition & food research (2024)

HFD-induced obesity significantly amplifies IL-17 signaling and exacerbates psoriasis, with a potential role played by Bcat2-mediated BCAAs metabolism. The study suggests that BCAA catabolism and PPAR γ-STAT3 exacerbate inflammation in psoriasis with obesity.

Keyphrases

high fat diet induced
insulin resistance
weight loss
metabolic syndrome
oxidative stress
type diabetes
high fat diet
amino acid
adipose tissue
diabetic rats
weight gain
atopic dermatitis
bariatric surgery
high glucose
skeletal muscle
cell proliferation