Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice.
Ryuichi NakajimaKeizo TakaoSatoko HattoriHirotaka ShojiNoboru H KomiyamaSeth G N GrantTsuyoshi MiyakawaPublished in: Neuropsychopharmacology reports (2019)
In Syngap1-/+ mice, we could reproduce most of the previously reported cognitive and emotional deficits. The decreased sensitivity to painful stimuli and impaired motor function that we found in Syngap1-/+ mice are consistent with the common characteristics of patients with SYNGAP-related ID. We further confirmed that the Syngap1 heterozygote mouse recapitulates the symptoms of ID and ASD patients.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- high fat diet induced
- autism spectrum disorder
- chronic kidney disease
- traumatic brain injury
- attention deficit hyperactivity disorder
- peritoneal dialysis
- early onset
- type diabetes
- physical activity
- patient reported outcomes
- wild type
- insulin resistance
- depressive symptoms
- sleep quality
- patient reported