ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance.

Massimiliano Mellone Klaudia Piotrowska Giulia Venturi Lija James Aleksandra Bzura Maria A Lopez Sonya James Chuan Wang Matthew J Ellis Christopher J Hanley Josephine F Buckingham Kerry L Cox Gareth Hughes Viia Valge-Archer Emma V King Stephen A Beers Vincent Jaquet George D D Jones Natalia Savelyeva A Emre Sayan Jason L Parsons Stephen T Durant Gareth J Thomas

Published in: Cancer research (2022)

ATM signaling supports the differentiation of myoCAFs to suppress T-cell infiltration and antitumor immunity, supporting the potential clinical use of ATM inhibitors in combination with checkpoint inhibition in myoCAF-rich, immune-cold tumors.

Keyphrases

dna damage
dna repair

dna damage response

oxidative stress

cell cycle