A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis.
Xiangjie ChenQiuyu WuZheng GongTengfei RenQian DuYukang YuanYibo ZuoYing MiaoJiuyi HeCaixia QiaoZhijin ZhengTingting ZhangLin HuangZhijun XieJun WangYueping ZhuChuanwu ZhuYang XuDepei WuFangyuan GongJunping ChengChengping WenHui ZhengPublished in: Journal of natural products (2022)
Rheumatoid arthritis (RA) is an autoimmune disease with nearly 1.6 billion patients worldwide and an incidence of 0.5-1%. In recent years, basic and clinical studies have revealed that immune cell responses and corresponding secretion of inflammatory factors are important in the control of RA development. Our study found that a natural plant ingredient, menthone, could be used as a potential antirheumatism compound. In vivo observations demonstrated that menthone alleviates collagen II-induced arthritis (CIA) in mice. Furthermore, we found that menthone regulates the number of Th1 and Th17 cells in CIA mice. Importantly, menthone significantly inhibits the release of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, in CIA mice. Our study suggests a potential component for the development of drugs to treat rheumatoid arthritis.
Keyphrases
- rheumatoid arthritis
- disease activity
- ankylosing spondylitis
- interstitial lung disease
- high fat diet induced
- induced apoptosis
- end stage renal disease
- newly diagnosed
- ejection fraction
- oxidative stress
- drug induced
- peritoneal dialysis
- risk factors
- metabolic syndrome
- wild type
- type diabetes
- human health
- skeletal muscle
- risk assessment
- endoplasmic reticulum stress
- insulin resistance
- patient reported