The role of galectin-3 in atrial fibrillation.
Grzegorz ProcykAleksandra CzaplaKamila JałochaKrzysztof OzierańskiMarcin GrabowskiAleksandra GaseckaPublished in: Journal of molecular medicine (Berlin, Germany) (2023)
Numerous risk factors for atrial fibrillation (AF) progression have been identified. However, the biomarkers mentioned in the guidelines do not have any clinically relevant predictive value. Some research groups investigated the potential utility of galectin-3 (gal-3) as a diagnostic, prognostic, and predictive biomarker in AF. In this review, we have thoroughly summarized the current data on the role of gal-3 in AF based on the original research in this field. Patients suffering from AF present with increased levels of gal-3. The concentration of gal-3 differs between patients with AF depending on the type of AF - it is higher in patients with persistent AF than in patients with paroxysmal AF. Multiple studies investigating the reappearance of AF in patients who underwent ablation have shown that gal-3 is a promising biomarker to predict the outcome of this therapy. Patients with increased levels of gal-3 are at higher risk of AF recurrence. Although the research considered in this work addressed many aspects of the role of gal-3 in AF, most of it has been conducted on a small group of patients. Therefore, further research and extensive clinical trials confirming described findings are highly warranted.
Keyphrases
- atrial fibrillation
- catheter ablation
- end stage renal disease
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- heart failure
- clinical trial
- chronic kidney disease
- ejection fraction
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- percutaneous coronary intervention
- machine learning
- patient reported outcomes
- artificial intelligence
- risk assessment
- left ventricular
- single molecule
- human health