Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice.

Jia YuChen LaiHoon ShimChengsong XieLixin SunCai-Xia LongJinhui DingYan LiHuai-Bin Cai

Published in: Molecular neurodegeneration (2018)

Overall, our findings demonstrate that p150Glued is particularly required to maintain the function and survival of SMNs during aging. P150Glued may exert its protective function through regulating the transportation of autophagosomes, lysosomes, and postsynaptic glutamate receptors in neurons.

Keyphrases

spinal cord
preterm infants
spinal cord injury
genome wide
high fat diet induced
gene expression
copy number
metabolic syndrome
skeletal muscle
insulin resistance
atrial fibrillation
wild type