A Novel Epitope Quality-Based Immune Escape Mechanism Reveals Patient's Suitability for Immune Checkpoint Inhibition.
Michael WessollySusann Stephan-FalkenauAnna StreubelRobert WernerSabrina BorchertSergej GriffElena MairingerRobert F H WalterTorsten BauerWilfried E E EberhardtTorsten Gerriet BlumKurt Werner SchmidJens KollmeierThomas MairingerFabian Dominik MairingerPublished in: Cancer management and research (2020)
The concept of altered epitope processing may help to understand immunotherapy failure. Especially when combined with PD-L1 status, this method can be used as a biomarker to identify patients not suitable for immunotherapy.