Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome.

Brigitta B GundersenWilliam T O'BrienMelanie D SchafflerMaria N SchultzTatsuya TsukaharaSandra Martin LorenzoValerie NalessoAlice H Luo ClaytonTed AbelJacqueline N CrawleySandeep Robert DattaYann Hérault

Published in: bioRxiv : the preprint server for biology (2023)

Experiments across four laboratories found that arbaclofen rescued cognitive deficits in mouse models of 16p11.2 deletion, without sedation or significant off-target behavioral effects.

Keyphrases

mouse model
case report
bone marrow
intensive care unit
mesenchymal stem cells
extracorporeal membrane oxygenation
acute respiratory distress syndrome
clinical evaluation