Population Pharmacokinetic Model of Piperacillin in Critically Ill Patients and Describing Interethnic Variation Using External Validation.
Cristina SanchesGeisa C S AlvesAndras FarkasSamuel Dutra da SilvaWhocely Victor de CastroFarah Maria Drummond ChequerFrancisco Beraldi-MagalhãesIgor Rafael Dos Santos MagalhãesAndré de Oliveira BaldoniMark D ChatfieldJeffrey LipmanJason Alexander RobertsSuzanne L ParkerPublished in: Antibiotics (Basel, Switzerland) (2022)
The primary pharmacokinetic parameters obtained from critically ill Brazilian patients were similar to those observed in studies performed in critically ill patients of other ethnicities. Based on our results, the use of dose adjustment based on creati-nine clearance is required in Brazilian patients.