Inconsistent reversal of HIV-1 latency ex vivo by antigens of HIV-1, CMV, and other infectious agents.
Thomas VollbrechtAaron O AngersteinBryson MenkeNikesh M KumarMichelli Faria de OliveiraDouglas D RichmanJohn C GuatelliPublished in: Retrovirology (2020)
In this group of patients in whom antiretroviral therapy was started during chronic infection, the latent reservoir does not appear to consistently reside in CD4 T cells of a predominant antigen-specificity. Peptide-antigens reversed HIV-1 latency ex vivo with modest and variable activity. When latency was reversed by specific peptides or proteins, it was proportionally greater than the extent of T cell activation, suggesting partial enrichment of the latent reservoir in cells of specific antigen-reactivity.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- hiv infected patients
- hiv testing
- men who have sex with men
- end stage renal disease
- hepatitis c virus
- ejection fraction
- chronic kidney disease
- prognostic factors
- dendritic cells
- peritoneal dialysis
- cell cycle arrest
- south africa
- patient reported outcomes
- signaling pathway
- immune response