An Integrated All-Natural Conductive Supramolecular Hydrogel Wearable Biosensor with Enhanced Biocompatibility and Antibacterial Properties.
Mengqian LiShuoxuan WangYuan LiXiaoyi MengYuping WeiYong WangYu ChenYin XiaoYue ChengPublished in: ACS applied materials & interfaces (2024)
Conductive hydrogels exhibit tremendous potential for wearable bioelectronics, biosensing, and health monitoring applications, yet concurrently enhancing their biocompatibility and antimicrobial properties remains a long-standing challenge. Herein, we report an all-natural conductive supramolecular hydrogel (GT 5 -DACD 2 -B) prepared via the Schiff base reaction between the biofriendly dialdehyde cyclodextrin and gelatin. The potent antibacterial agent fusidic acid (FA) is incorporated through host-guest inclusion, enabling 100% inhibition of Staphylococcus aureus proliferation. The biocompatibility of our hydrogel is bolstered with tannic acid (TA) facilitating antibacterial effects through interactions with gelatin, while borax augments conductivity. This supramolecular hydrogel not only exhibits stable conductivity and rapid response characteristics but also functions as a flexible sensor for monitoring human movement, facial expressions, and speech recognition. Innovatively integrating biocompatibility, antimicrobial activity, and conductivity into a single system, our work pioneers a paradigm for developing multifunctional biosensors with integrated antibacterial functionalities, paving the way for advanced wearable bioelectronics with enhanced safety and multifunctionality.
Keyphrases
- tissue engineering
- staphylococcus aureus
- silver nanoparticles
- anti inflammatory
- heart rate
- water soluble
- drug delivery
- wound healing
- endothelial cells
- hyaluronic acid
- essential oil
- healthcare
- public health
- energy transfer
- mental health
- signaling pathway
- gold nanoparticles
- biofilm formation
- health information
- pseudomonas aeruginosa
- human health
- quantum dots
- sensitive detection
- cancer therapy
- risk assessment
- soft tissue
- mass spectrometry
- social media