Analysis of rare coding variants in 200,000 exome-sequenced subjects reveals novel genetic risk factors for type 2 diabetes.

Published in: Diabetes/metabolism research and reviews (2021)

Rare genetic variants make an identifiable contribution to T2D in a small number of cases but these may provide valuable insights into disease mechanisms. As larger samples become available it is likely that additional genetic factors will be identified.

Keyphrases

copy number
type diabetes
genome wide
cardiovascular disease
insulin resistance
gene expression
metabolic syndrome
adipose tissue
weight loss