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Safety of Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Liver Metastases from Ocular Melanoma Using the Delcath Systems' Second-Generation Hemofiltration System: A Prospective Non-randomized Phase II Trial.

T Susanna MeijerMark C BurgmansMarta FioccoLioe-Fee de Geus-OeiEllen KapiteijnEleonora M de LeedeChristian H MartiniRutger W van der MeerFred G J TijlAlexander L Vahrmeijer
Published in: Cardiovascular and interventional radiology (2019)
M-PHP using the GEN 2 filter has an acceptable safety and toxicity profile, and seems to reduce hematologic toxicity when compared to M-PHP with a first-generation filter. Prior therapy of liver metastases is a possible predictive factor in developing grade 3/4 hematologic toxicity.
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