PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis.

Shuai LuoXiao-Feng LiYing-Li YangBiao SongSha WuXue-Ni NiuYuan-Yuan WuWen ShiCheng HuangJun Li

Published in: Advances in rheumatology (London, England) (2022)

Result showed that the function of PLCL1 in RA FLS might be related to the NLRP3 inflammasomes. We finally confirmed our hypothesis with the NLRP3 inhibitor INF39. Our results suggested that PLCL1 might promote the inflammatory response of RA FLS by regulating the NLRP3 inflammasomes.

Keyphrases

rheumatoid arthritis
inflammatory response
nlrp inflammasome
disease activity
ankylosing spondylitis
oxidative stress
interstitial lung disease
systemic lupus erythematosus
immune response
toll like receptor
drug induced