Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.
Martyna SzpakowskaAmanda M NevinsMax MeyrathDavid RhaindsThomas D'huysFrançois Guité-VinetNadine DupuisPierre-Arnaud GauthierManuel CounsonAndrew KleistGeneviève St-OngeJulien HansonDominique ScholsBrian F VolkmanNikolaus HevekerAndy ChevignéPublished in: British journal of pharmacology (2018)
These results suggest a different interaction mechanism between this atypical receptor and its ligands and illustrate its strong propensity to activation.
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