Identification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients.

Marianna ButtarelliAlessandra CiucciFernando PalluzziGiuseppina RaspaglioClaudia MarchettiEmanuele PerroneAngelo MinucciLuciano GiacòAnna FagottiGiovanni ScambiaDaniela Gallo

Published in: Journal of experimental & clinical cancer research : CR (2022)

Using machine-learning techniques we have identified a gene signature that could predict response to first-line chemotherapy in BRCAwt HGSOC patients, providing a useful tool towards personalized treatment modalities.

Keyphrases

high grade
end stage renal disease
newly diagnosed
chronic kidney disease
genome wide
wild type
gene expression
radiation therapy
bioinformatics analysis