Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.

Simone Cristina Méo NiciuraPolyana Cristine TiziotoCaroline Valério MoraesGiovanna Gabrielle CruvinelAna Cláudia Alexandre de AlbuquerqueRaul Costa Mascarenhas SantanaAna Carolina de Souza ChagasSergio Novita EstevesMagda Vieira BenavidesAlessandro Francisco Talamini do Amarante

Published in: Parasites & vectors (2019)

This study expands knowledge on genome-wide molecular events underlying H. contortus resistance to monepantel. The identification of a genome region harboring major genes previously associated with monepantel resistance supports the results of the employed X-QTL approach. In addition, a deletion in exon 11 of the mptl-1 gene should be further investigated as the putative causal mutation leading to monepantel resistance.

Keyphrases

genome wide
dna methylation
healthcare
high density
copy number
high resolution
gene expression
climate change
mass spectrometry