Microglial Activation and Connectivity in Alzheimer Disease and Aging.
Boris-Stephan RauchmannMatthias BrendelNicolai FranzmeierLena TrappmannMirlind ZaganjoriErsin ErsoezlueEstrella Morenas-RodriguezSelim GuerselLena BurowCarolin KurzJan HaeckertMaia TatòJulia UtechtBoris PapazovOliver PogarellDaniel JanowitzKatharina BuergerMichael EwersCarla PalleisEndy WeidingerGloria BiecheleSebastian SchusterAnika FinzeFlorian EckenweberRainer RupprechtAxel RomingerOliver GoldhardtTimo GrimmerDaniel KeeserSophia StoeckleinOlaf DietrichPeter BartensteinJohannes LevinGünter HöglingerRobert PerneczkyPublished in: Annals of neurology (2022)
Microglial activation distributes preferentially along highly connected brain regions, similar to tau pathology. These findings support the important role of microglia in neurodegeneration, and we speculate that pathology spreads throughout the brain along vulnerable connectivity pathways. ANN NEUROL 2022;92:768-781.