Detection of prostate cancer-specific transcripts in extracellular vesicles isolated from post-DRE urine.

Kathryn L PellegriniDattatraya PatilKristen J S DouglasGrace LeeKathryn WehrmeyerMersiha TorlakJeremy ClarkColin S CooperCarlos S MorenoMartin G Sanda

Published in: The Prostate (2017)

Post-DRE urine EVs are a viable source of prostate-derived RNAs for biomarker discovery and prostate cancer status can be distinguished from analysis of these specimens. Continued analysis of urine EVs offers the potential discovery of novel biomarkers for pre-biopsy prostate cancer detection.

Keyphrases

prostate cancer
radical prostatectomy
small molecule
high throughput
loop mediated isothermal amplification
label free
real time pcr
risk assessment
benign prostatic hyperplasia
climate change
sensitive detection