The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts.

Linjie ZhaoWei WangShuang HuangZhengnan YangLian XuQilian YangXiu ZhouJinjin WangQiuhong ShenChenlu WangXiaobing LeMin FengNianxin ZhouWayne Bond LauBonnie LauShaohua YaoTao YiXin WangXia ZhaoYuquan WeiShengtao Zhou

Published in: Genome biology (2018)

Our data illustrate a novel post-transcriptional network that links cancer progression and immunomodulation within the tumor microenvironment through SORBS2-mediated transcript stabilization.

Keyphrases

binding protein
papillary thyroid
squamous cell carcinoma
small cell lung cancer
gene expression
electronic health record
squamous cell
signaling pathway
big data
rna seq
lymph node metastasis
childhood cancer
machine learning
oxidative stress
nucleic acid
young adults