Comprehensive Genomic Profiling of 274 Thymic Epithelial Tumors Unveils Oncogenic Pathways and Predictive Biomarkers.

Nicolas Girard Clémence BasseAlexa SchrockShakti RamkissoonKeith KillianJeffrey S Ross

Published in: The oncologist (2022)

Our cohort is the largest available so far, reporting on CGP of thymic epithelial tumors in the setting of advanced disease. The identification of clinically relevant genomic alterations in the KIT, PI3K, CDKN2A/B, or NTRK genes provides a strong rationale for potential precision medicine approaches using targeted agents. A subset of thymic carcinomas show high tumor mutation burden, what may be a predictor of efficacy of immune checkpoint inhibitors.

Keyphrases

copy number
bioinformatics analysis
genome wide
high grade
cancer therapy
transcription factor
single cell
gene expression
risk assessment
human health
genome wide identification