Transcriptomic Landscape of Lower Grade Glioma Based on Age-Related Non-Silent Somatic Mutations.
YoungJoon ParkJeongMan ParkJu Won AhnJeong Min SimSu Jung KangSuwan KimSo Jung HwangSong-Hee HanKyoung Su SungJaeJoon LimPublished in: Current oncology (Toronto, Ont.) (2021)
Glioma accounts for 80% of all malignant brain tumours and is the most common adult primary brain tumour. Age is an important factor affecting the development of cancer, as somatic mutations accumulate with age. Here, we aimed to analyse the significance of age-dependent non-silent somatic mutations in glioma prognosis. Histological tumour grade depends on age at diagnosis in patients with IDH1, TP53, ATRX, and EGFR mutations. Age of patients with wild-type IDH1 and EGFR increased with increase in tumour grade, while the age of patients with IDH1 or EGFR mutation remained constant. However, the age of patients with EGFR mutation was higher than that of patients with IDH1 mutation. The hierarchical clustering of patients was dominantly separated by IDH1 and EGFR mutations. Furthermore, patients with IDH1 mutation were dominantly separated by TP53 and ATRX double mutation and its double wild-type counterpart. The age of patients with ATRX and TP53 mutation was lower than that of patients with wild-type ATRX and TP53. Patients with the double mutation showed poorer prognosis than those with the double wild type genotype. Unlike IDH1 mutant, IDH1 wild-type showed upregulation of expression of epithelial mesenchymal transition associated genes.
Keyphrases
- wild type
- small cell lung cancer
- epidermal growth factor receptor
- tyrosine kinase
- epithelial mesenchymal transition
- single cell
- end stage renal disease
- chronic kidney disease
- squamous cell carcinoma
- white matter
- newly diagnosed
- young adults
- multiple sclerosis
- resting state
- blood brain barrier
- low grade
- transcription factor
- patient reported outcomes
- functional connectivity