Celastrol reduces lung inflammation induced by multiwalled carbon nanotubes in mice via NF-κb-signaling pathway.
Tao-Lin QingXuan-Yao JiangJin-Feng LiQi ShenXin-Yi ZhaoLi-Jun RenXiao-Yu DaiJi-Qian-Zhu ZhangWen-Jing ShiXiao-Fang ZhangBin ZhangLang YanJi-Kuai ChenJiang-Bo ZhuPublished in: Inhalation toxicology (2024)
Multiwalled carbon nanotubes (MWCNTs) have numerous applications in the field of carbon nanomaterials. However, the associated toxicity concerns have increased significantly because of their widespread use. The inhalation of MWCNTs can lead to nanoparticle deposition in the lung tissue, causing inflammation and health risks. In this study, celastrol, a natural plant medicine with potent anti-inflammatory properties, effectively reduced the number of inflammatory cells, including white blood cells, neutrophils, and lymphocytes, and levels of inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, in mice lungs exposed to MWCNTs. Moreover, celastrol inhibited the activation of the NF-κB-signaling pathway. This study confirmed these findings by demonstrating comparable reductions in inflammation upon exposure to MWCNTs in mice with the deletion of NF-κB (P50 -/- ). These results indicate the utility of celastrol as a promising pharmacological agent for preventing MWCNT-induced lung tissue inflammation.
Keyphrases
- oxidative stress
- signaling pathway
- induced apoptosis
- carbon nanotubes
- pi k akt
- cell cycle arrest
- diabetic rats
- anti inflammatory
- high fat diet induced
- lps induced
- epithelial mesenchymal transition
- endoplasmic reticulum stress
- rheumatoid arthritis
- nuclear factor
- walled carbon nanotubes
- cell proliferation
- peripheral blood
- immune response
- adipose tissue
- type diabetes
- cell death