IGF-1 Mediated Neuroprotective Effects of Olfactory-Derived Mesenchymal Stem Cells on Auditory Hair Cells.

Marc J W LammersEmily YoungAnat YanaiIshaq A ViringipurampeerTrung N LeLouise V StraatmanBrian D WesterbergKevin Gregory-Evans

Published in: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (2024)

This study has shown that OMSCs may mitigate auditory hair cell stereocilia degeneration. Their neuroprotective effects may, at least partially, be ascribed to their enhanced IGF-1 secretory abilities compared to AMSCs.

Keyphrases

induced apoptosis
working memory
cell cycle arrest
pi k akt
binding protein
single cell
hearing loss
cell therapy
growth hormone
signaling pathway
oxidative stress
stem cells
cell death
mesenchymal stem cells
cell proliferation
bone marrow