Autophagy promotes phagocytosis and clearance of Treponema pallidum via the NLRP3 inflammasome in macrophages.

S-L XuY LinX-Z ZhuD LiuM-L TongL-L LiuTian-Ci Yang Li-Rong Lin

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)

Treponema pallidum induces autophagy in macrophages to promote phagocytosis and clearance. The NLRP3 inflammasome modulates autophagy and phagocytosis in vitro. These data may be useful for understanding the host-pathogen relationship and establish the groundwork for strategies to combat syphilis.

Keyphrases

nlrp inflammasome
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
human immunodeficiency virus
machine learning