Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout.

Zengmiao WangYing ZhaoAmanda Phipps-GreenRu Liu-BryanArnoldas CeponisDavid L BoyleJun WangTony R MerrimanWei WangRobert Terkeltaub

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

These findings of differential DNA methylation of networked signaling, transcriptional, innate and adaptive immunity, and osteoclastogenesis genes and pathways suggest that they could serve as novel therapeutic targets in the management of flares, tophi, chronic synovitis, and bone erosion in patients with gout.

Keyphrases

dna methylation
genome wide
immune response
gene expression
bone loss
uric acid
transcription factor
genome wide identification
copy number
bioinformatics analysis
bone mineral density
heat shock
genome wide analysis
inflammatory response