Association of Cortical Lesions With Regional Glutamate, GABA, N -Acetylaspartate, and Myoinositol Levels in Patients With Multiple Sclerosis.

Cortical lesions are associated with local increases in glutamate and a reduction in GABA concentration within the lesional or perilesional tissue. Further studies are needed to investigate the causal relationship between cortical lesions and changes in neurotransmitter concentrations.