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Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

Robert E SorgeJosiane C S MapplebeckSarah RosenSimon BeggsSarah TavesJessica K AlexanderLoren J MartinJean-Sebastien AustinSusana G SotocinalDi ChenMu YangXiang Qun ShiHao HuangNicolas J PillonPhilip J BilanYuShan TuAmira KlipRu-Rong JiJi ZhangMichael W SalterJeffrey S Mogil
Published in: Nature neuroscience (2015)
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
Keyphrases
  • chronic pain
  • neuropathic pain
  • pain management
  • drug induced
  • high fat diet induced
  • inflammatory response
  • mental health
  • metabolic syndrome
  • insulin resistance