Genetic variants of UDP-glucuronosyltransferase 1A genes are associated with disease presentation and outcome in primary sclerosing cholangitis.

Tobias J Weismüller Taotao ZhouSandra KalthoffHenrike LenzenMichael P MannsChristian P Strassburg

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

This large cohort shows an association with single nucleotide polymorphisms of the UGT1A1, UGT1A3 and UGT1A7 genes and outcome in PSC. Thus, UGT1A variants may represent a tool for the prognostic stratification of PSC patients and establish a link between disease progression and the regulation of detoxification by glucuronidation in PSC.

Keyphrases

end stage renal disease
genome wide
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
bioinformatics analysis
genome wide identification
gene expression
patient reported outcomes
case report
transcription factor
ulcerative colitis