A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension.

Lai-Ming YungIvana NikolicSamuel D Paskin-FlerlageR Scott PearsallRavindra KumarPaul B Yu

Published in: American journal of respiratory and critical care medicine (2017)

Our findings are consistent with a pathogenetic role of TGF-β1/3, demonstrating the efficacy and tolerability of selective TGF-β ligand blockade for improving hemodynamics, remodeling, and survival in multiple experimental PH models.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
pulmonary hypertension
open label
pulmonary arterial hypertension
signaling pathway
coronary artery
study protocol