The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity.
Janne HukkanenJohanna PuurunenTuulia HyötyläinenMarkku J SavolainenAimo RuokonenLaure Morin-PapunenMatej OrešičTerhi PiltonenJuha S TapanainenPublished in: British journal of clinical pharmacology (2015)
The results establish atorvastatin as an inhibitor of CYP3A4 activity. Furthermore, 4βHC : C is a useful index of CYP3A4 activity, including the conditions with altered cholesterol concentrations.
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