Systematic Review of the Clinical Characteristics and Management of Isaac Syndrome.
Mustafa Al-ChalabiPrajwal HegdeSara R MooreYasmeen AbouainainMyles KeenerHira ParvezJeremy EidSidra SaleemAjaz SheikhPublished in: Journal of clinical neuromuscular disease (2023)
IS a rare neuromuscular syndrome that tends to affect middle-aged men. These patients should be screened for thymoma and other malignancies such as lymphomas. The management of IS symptoms can be challenging, but based on our review, the combination of multiple immunosuppressives such as IV steroids and plasmapheresis with anticonvulsants such as carbamazepine seems to achieve the best results.