Stereoselective copper-catalyzed heteroarene C-H functionalization/Michael-type annulation cascade with α-diazocarbonyls.
Aabid BhatNathan TuckerJian-Bin LinHuck K GroverPublished in: Chemical communications (Cambridge, England) (2021)
A stereoselective, copper-catalyzed, arene C(sp2)-H functionalization/Michael-type annulation reaction involving α-diazocarbonyl compounds has been developed. The method features low catalyst loadings, high yields, and excellent regio and stereoselectivity, in the synthesis of various heteroaromatic frameworks by employing indoles as the arene partner.