MicroRNA-122 regulates polyploidization in the murine liver.
Shu-Hao HsuEvan R DelgadoP Anthony OteroKun-Yu TengHuban KutayKolin M MeehanJustin B MoroneyJappmann K MongaNicholas J HandJoshua R FriedmanKalpana GhoshalAndrew W DuncanPublished in: Hepatology (Baltimore, Md.) (2016)
Among the different signals that have been associated with hepatic polyploidy, miR-122 is the first liver-specific signal identified; our data demonstrate that miR-122 is both necessary and sufficient in liver polyploidization, and these studies will serve as the foundation for future work investigating miR-122 in liver maturation, homeostasis, and disease. (Hepatology 2016;64:599-615).