Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study.

Guoliang QiaoXiaoli WangLei ZhouXinna ZhouYuguang SongShuo WangLei ZhaoMichael A MorseAmy HobeikaJin SongXin YiXuefeng XiaJun RenHerbert Kim Lyerly

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

DC-CIK combined with S-1 plus cisplatin provided a favorable PFS and OS in patients with AGC and the combination therapy was safe with tolerable toxicities. Clinical efficacy correlated with decreases in ctDNA mutational profiles and restored TCR repertoire.

Keyphrases

combination therapy
dendritic cells
regulatory t cells
cell therapy
single cell
high glucose
diabetic rats
neoadjuvant chemotherapy
immune response
stem cells
squamous cell carcinoma
drug induced
circulating tumor
platelet rich plasma