Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma.

Anna ReustleLena-Sophie MenigPatrick LeutholdUte HofmannViktoria StühlerChristian SchmeesMichael BeckerMathias HaagVerena KlumppStefan WinterFlorian A BüttnerSteffen RauschJörg HennenlotterFalko FendMarcus ScharpfArnulf StenzlJens BedkeMatthias SchwabElke Schaeffeler

Published in: Clinical and translational medicine (2022)

Since efficient glutamine utilisation, which is essential for ccRCC tumours, depends on NNMT, small-molecule NNMT inhibitors provide a novel therapeutic strategy for ccRCC and act as sensitizers for combination therapies.

Keyphrases

small molecule
squamous cell carcinoma
small cell lung cancer
protein protein
solar cells
emergency department