I 2 /DMSO-Promoted Synthesis of Diaryl Sulfide- and Selenide-Embedded Arylhydrazones.
Arun DhureySubhro MandalAnimesh PramanikPublished in: The Journal of organic chemistry (2023)
Functionalization and derivatization of arylhydrazones are important in pharmaceutical, medicinal, material, and coordination chemistry. In this regard, a facile I 2 /DMSO-promoted cross-dehydrogenative coupling (CDC) for direct sulfenylation and selenylation of arylhydrazones has been accomplished utilizing arylthiols/arylselenols at 80 °C. This method provides a metal-free benign route for the synthesis of a variety of arylhydrazones embedded with diverse diaryl sulfide and selenide moieties in good to excellent yield. In this reaction, molecular I 2 acts as a catalyst, and DMSO is utilized as a mild oxidant as well as solvent to produce several sulfenyl and selenyl arylhydrazones through a CDC-mediated catalytic cycle.
Keyphrases
- room temperature
- ionic liquid
- reduced graphene oxide
- cell cycle
- highly efficient
- ms ms
- metal organic framework
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- quantum dots
- visible light
- cell proliferation
- simultaneous determination
- gas chromatography mass spectrometry
- crystal structure
- liquid chromatography
- high resolution
- single molecule
- tandem mass spectrometry
- drug discovery
- gas chromatography
- high resolution mass spectrometry