The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats.
Simon D BrandtHailey M WaltersJohn S PartillaBruce E BloughPierce V KavanaghMichael H BaumannPublished in: Psychopharmacology (2020)
Overall, benzofurans are more potent than MDA in vitro and in vivo, producing sustained stimulant-like effects in rats. These data suggest that benzofuran-type compounds may have abuse liability and could pose risks for adverse effects, especially if used in conjunction with abused drugs or medications which enhance monoamine transmission in the brain.
Keyphrases
- functional connectivity
- resting state
- breast cancer cells
- attention deficit hyperactivity disorder
- cell cycle arrest
- electronic health record
- human health
- big data
- white matter
- cell death
- risk assessment
- multiple sclerosis
- climate change
- autism spectrum disorder
- cell proliferation
- data analysis
- intimate partner violence