Effects of Gundelia tournefortii L. on biochemical parameters, antioxidant activities and DNA damage in a rat model of experimental obesity.
Bedia BatiIsmail CelikN Eray VuranAbdullah TuranElif Ebru AlkanAli Kemal ZirekPublished in: Brazilian journal of biology = Revista brasleira de biologia (2021)
The present study was designed to investigate the effects of Gundelia tournefortii L. plant extract on different tissues in terms of DNA damage, biochemical and antioxidant parameter values in rats with high-calorie diets. With this aim, Wistar albino male rats were divided into 4 groups containing 6 rats each and the study was completed over 12 weeks duration. At the end of the implementation process over the 12 weeks, rats were sacrificed and blood and tissue samples were obtained. Analyses were performed on blood and tissue samples. According to results for DNA damage (8-OHdG), in brain tissue the OG2 group was significantly reduced compared to the NC group. For MDA results in liver tissue, OG1 and OG2 groups were determined to increase by a significant degree compared to the control group, while the OG2 group was also increased significantly compared to the obese group. In terms of the other parameters, comparison between the groups linked to consumption of a high calorie diet (HCD) and administration of Gundelia tournefortii L. in terms of antioxidant activities and serum samples obtained statistically significant results. Gundelia tournefortii L. plant extracts had effects that may be counted as positive on antioxidant parameter activity and were especially identified to improve DNA damage and MDA levels in brain tissues. Additionally, consumption of Gundelia tournefortii L. plant extract in the diet may have antiobesity effects; thus, it should be evaluated for use as an effective weight-loss method and as a new therapeutic agent targeting obesity.
Keyphrases
- weight loss
- dna damage
- oxidative stress
- bariatric surgery
- roux en y gastric bypass
- gastric bypass
- dna repair
- anti inflammatory
- metabolic syndrome
- gene expression
- healthcare
- weight gain
- type diabetes
- insulin resistance
- resting state
- primary care
- obese patients
- white matter
- breast cancer cells
- body mass index
- physical activity
- brain injury
- multiple sclerosis
- cell proliferation
- adipose tissue
- cell death
- functional connectivity
- quality improvement
- cell wall
- cancer therapy
- drug delivery