The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation.
Danielle R BrunsPhilip D TatmanRoshni S KalkurR Dale BrownKurt R StenmarkPeter M ButtrickLori A WalkerPublished in: PloS one (2019)
These data suggest that paracrine factor(s) released by Cfib from the PH calf signal a phenotypic transformation in a population of cardiomyocytes that likely contributes to RV dysfunction. Therapies targeting this process, such as inhibition of periostin, have the potential to prevent RV dysfunction.