The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation.

Danielle R BrunsPhilip D TatmanRoshni S KalkurR Dale BrownKurt R StenmarkPeter M ButtrickLori A Walker

Published in: PloS one (2019)

These data suggest that paracrine factor(s) released by Cfib from the PH calf signal a phenotypic transformation in a population of cardiomyocytes that likely contributes to RV dysfunction. Therapies targeting this process, such as inhibition of periostin, have the potential to prevent RV dysfunction.

Keyphrases

mycobacterium tuberculosis
oxidative stress
electronic health record
angiotensin ii
cancer therapy
big data
risk assessment
human health
machine learning
deep learning