Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.

Lu TangHuan ZhangFen ZhouQiuzhe WeiMengyi DuJianghua WuChenggong LiWenjing LuoJie ZhouXindi WangZhaozhao ChenYinqiang ZhangZhongpei HuangZhuolin WuYuxi WenHuiwen JiangDanying LiaoHaiming KouWei XiongHeng MeiYu Hu

Published in: Cancer communications (London, England) (2024)

These findings confirm that autophagy signaling in B-cell malignancies is essential for the effective cytotoxic function of CAR-T cells and thereby pave the way for the development of autophagy-targeting strategies to improve the clinical efficacy of CAR-T cell immunotherapy.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
cancer therapy
papillary thyroid
squamous cell carcinoma
lymph node metastasis